Pharmaceutical Fermentation Broth Separation Decanter Centrifuge GMP SS316L Mycelium Recovery 5m3/H

The LW280 pharmaceutical fermentation broth separation decanter centrifuge is a sanitary grade machine designed for the primary separation of mycelium and biomass from antibiotic, enzyme, vitamin and other fermentation broths. In pharmaceutical manufacturing, downstream purification trains depend on a clean, particle free liquid phase, and any loss of valuable product with the solids directly affects yield and production cost. This decanter performs the initial solid liquid separation gently enough to avoid cell disruption, yet powerfully enough to deliver a clear supernatant for subsequent microfiltration or extraction steps. With a bowl speed of 4200 rpm and a separation force of 3500 G, the LW280 handles viscous, non Newtonian broths that quickly blind conventional filter presses.

The machine is engineered to GMP oriented requirements. All product contact surfaces are manufactured from SS316L stainless steel with a surface finish that meets hygienic standards, and the design avoids dead zones where product could stagnate. The rotating assembly is sealed with food grade elastomers and the machine can be cleaned in place with hot water, caustic and sanitizing solutions. Because fermentation campaigns switch between products, the LW280 is equipped with quick release feed pipe, easily removable conveyor and inspection ports that allow thorough cleaning and visual inspection between batches. Process data such as torque, speed and temperature are recorded by the control system, supporting batch documentation and validation.

• GMP oriented design: SS316L product contact parts with smooth welds and hygienic surface finish reduce contamination risk.
• CIP capability: the machine is designed for cleaning in place with caustic and hot water cycles between production campaigns.
• High speed separation: 4200 rpm bowl speed provides 3500 G to handle viscous broths and fine biomass without process aids.
• Gentle product handling: optimized feed accelerator minimizes shear, protecting shear sensitive fermentation products and enzymes.
• Fully documented operation: PLC records process parameters for batch reports and supports validation protocols.
• Quick strip down design: tool free access to the conveyor and feed pipe shortens cleaning time between product changes.

The LW280 is applied in pharmaceutical plants producing antibiotics such as penicillin and tetracycline, enzymes, organic acids, vitamins, probiotics and recombinant fermentation products. It separates fungal mycelium, bacterial cells and yeast biomass from culture broth, clarifies broths before chromatography and concentrates biomass for further processing. Beyond pharmaceuticals, the same sanitary design suits food supplement fermentation, cosmetic ingredient production and biotech laboratories scaling up new fermentation processes.

Each LW280 is delivered with material certificates for all product contact parts, a surface finish inspection report and a full speed factory test certificate. The machine is packed in a fumigation free wooden case with the rotating assembly fixed by transport locks, and all openings are sealed with clean plastic covers to prevent contamination during shipping. Our documentation package includes an IQ OQ oriented manual, electrical drawings, spare parts list and cleaning instructions. The warranty period is 12 months, and our service engineers can support installation, commissioning and operator training either on site or through remote video assistance.